Python screams on .NET
Jim Hugunin, of AspectJ and JPython/Jython, has made a preliminary version of Python that runs pretty fast on .NET.
Here's an excerpt from his .NET Language Devs mailing list post:
The early results with IronPython show that Python compiled to IL can run fast. On the standard pystone benchmark, IronPython-0.1 is 70% faster than CPython-2.3. The numbers for pystone as well as several micro-benchmarks are shown below. For ease of comparison, all times are normalized to Python-2.3. Smaller numbers indicate faster performance.
IronPython-0.1 Python-2.3 Python-2.1 Jython-2.1
pystone 0.58 1.00 1.29 1.61
function call 0.19 1.00 1.12 1.33
integer add 0.59 1.00 1.18 1.08
string.replace 0.92 1.00 1.00 1.40
range(bigint) 5.57 1.00 1.09 16.02
eval("2+2") 66.97 1.00 1.58 91.33
Via Thinking In .Net.